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Dr.G.Gopalan
Department: Dept. of Genetics, Centre for Excellence in Genomic Sciences
E-mail ids: ggopalan85@hotmail.com; g.gopalan@nrcbsmku.org
Phone numbers: +91 9600428129
A brief write up about the research work:
Aurora kinases evolve as a new family of mitotic, centrosome and microtubule-associated kinases that regulate the structure and function of centrosomes and mitotic spindle. One of its members, Aurora-A kinase, has been shown to play an oncogenic role in cancer. As an important regulator of cell division with its oncogenic properties, Aurora-A is a potential target for inhibitory molecules that could inhibit cell cycle progression and thus could be useful as cancer therapeutic. In recent years, Aurora-A expression has been emerging as a means to predict the outcome of the disease and Aurora-A as a promising anti-cancer target. Our research activities are directed towards understanding the negative regulation of Aurora-A kinase as well as Aurora-A-linked signaling pathways contributing towards tumorigenesis and chemoresistance.
Honors and Recognitions:
1987-1989 Humboldt Fellow, Alexander von Humboldt Foundation, FRG.
2000 Young Investigator Scholar Award, American Association for Cancer
Research
2010 – Invited member of the Review Editorial Board of Frontiers in vascular
physiology
Area of Research: Cancer cell signaling, Epigenomics
Ongoing Research projects:
Title: “Expression profiling of miRNAs and their regulatory circuit in A2M induced
hypertrophy and heart failure”
Agency: Department of Biotechnology
Amount: INR 35,35,000
Role: CoPI
Recent Publications:
1. Dullo I, Gopalan, G, Melino G and Sabapathy K (2010). "The anti-apoptotic DeltaNp73 is degraded in a c-Jun-dependent manner upon genotoxic stress through the antizyme-mediated pathway". Proc. Natl. Acad. Sci. USA. 107:4902-07.
2. Heng HL, Yansong Z and Gopalan, G. (2008) Dowregulation of Aurora-A kinase overrides estrogen-induced growth and chemoresistance in breast cancer cells. Endocrine Related cancers 15: 765-775.
3. Lim SK and Gopalan, G(2007) Antizyme1 mediates AURKAIP1-dependent degradation of Aurora-A. Oncogene 26:6593-603
4. Lim SK and Gopalan, G (2007) Aurora-A kinase interacting protein (AURKAIP1) promotes Aurora-A degradation through an alternative ubiquitin-independent pathway. Biochem J. 403:119-27.
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